World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Gwas of Follicular Lymphoma Reveals Allelic Heterogeneity at 6P21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma, Volume 7

By Gibson, Greg

Click here to view

Book Id: WPLBN0003931644
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Gwas of Follicular Lymphoma Reveals Allelic Heterogeneity at 6P21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma, Volume 7  
Author: Gibson, Greg
Volume: Volume 7
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Gibson, G. (n.d.). Plos Genetics : Gwas of Follicular Lymphoma Reveals Allelic Heterogeneity at 6P21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma, Volume 7. Retrieved from http://ebooklibrary.org/


Description
Description : Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL–associated locus on 6p21.32, rs2647012 (ORcombined = 0.64, Pcombined=2610221) located 962 bp away from rs10484561 (r2,0.1 in controls). After mutual adjustment, the associations at the two SNPs remained genome-wide significant (rs2647012:ORadjusted = 0.70, Padjusted=4610212: rs10484561:ORadjusted = 1.64, Padjusted=5610215). Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk. Moreover, in a follow-up analysis of the top 6 FL–associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (ORcombined = 1.36, Pcombined = 1.461027). Our results reveal the presence of allelic heterogeneity within the HLA class II region influencing FL susceptibility and indicate a possible shared genetic etiology with diffuse large B-cell lymphoma. These findings suggest that the HLA class II region plays a complex yet important role in NHL.

 

Click To View

Additional Books


  • Plos Genetics : Palmitoylation Regulates... (by )
  • Plos Genetics : Consequences of Lineage-... (by )
  • Plos Genetics : the Drosophila Melanogas... (by )
  • Plos Genetics : Genome-wide Identificati... (by )
  • Plos Genetics : Systematic Detection of ... (by )
  • Plos Genetics : Integrating 5-hydroxymet... (by )
  • Plos Genetics : Role of Apobec3 in Genet... (by )
  • Plos Genetics : a Quantitative Compariso... (by )
  • Plos Genetics : Identification of New Ge... (by )
  • Plos Genetics : Modulating the Strength ... (by )
  • Plos Genetics : Signalling Pathways Invo... (by )
  • Plos Genetics : Cdk2 is Required for P53... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.